This algorithm assists providers in screening for syphilis starting with an initial nontreponemal test (e.g., Venereal Disease Research Laboratory [VDRL] or rapid plasma reagin [RPR] test) then confirming positive results with a reflex treponemal antibody detection test (e.g., fluorescent treponemal antibody absorbed [FTA-ABS] test, chemoluminescence immunoassays [CIA], enzyme immunoassays [EIA], or T pallidum particle agglutination [TP-PA] test).